Neohesperidin , Analysis of standard products, ≥97% , 13241-33-3

Synonym(s):
(S)-4′-Methoxy-3′,5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside];Hesperetin 7-O-neohesperidoside;Neohesperidin;NSC 31048

CAS NO.：13241-33-3

Empirical Formula: C28H34O15

Molecular Weight: 610.56

MDL number: MFCD16661259

EINECS: 236-216-9

PRODUCT Properties

• Melting point: 239-243°C
• Boiling point: 933.7±65.0 °C(Predicted)
• Density: 1.65±0.1 g/cm3(Predicted)
• vapor pressure: 0Pa at 20℃
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO (Slightly), Pyridine (Slightly)
• pka: 7.14±0.40(Predicted)
• form: Solid
• color: White to Off-White
• Water Solubility: 3.98mg/L at 20℃
• BRN: 74945
• InChIKey: ARGKVCXINMKCAZ-RTFRIYMLSA-N
• LogP: -0.69 at 20℃

Description and Uses

Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities. In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL). In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity. In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.

Neohesperidin exhibits lipid-regulating effects in vivo and in vitro. It is a main flavonoid in citrus byproducts (CBP) which possesses anti-oxidant activity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: DJ2981400
• F: 10-21
• HS Code: 29389090