3-Morpholinone , >98.0%(GC) , 109-11-5

CAS NO.：109-11-5

Empirical Formula: C4H7NO2

Molecular Weight: 101.1

MDL number: MFCD00631009

EINECS: 203-647-9

PRODUCT Properties

• Melting point: 103.0 to 107.0 °C
• Boiling point: 142°C/7mmHg(lit.)
• Density: 1.122±0.06 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: soluble in Methanol
• form: powder to crystal
• pka: 14.37±0.20(Predicted)
• color: White to Almost white

Description and Uses

3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.

3-Morpholinone is used as a reactant in the synthesis of 3-Morpholinone derivates. An example of this is 4-(4-Aminophenyl)-3-morpholinone, the key intermediate in the synthesis of Rivaroxaban (an anticoagulant).

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302+H312+H332-H315-H317-H318
• Precautionary statements: P280
• Safety Statements: 24/25
• HS Code: 29349990