Mitoxantrone dihydrochloride , ≥97% , 70476-82-3
Synonym(s):
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride;Mitoxantrone dihydrochloride
CAS NO.：70476-82-3
Empirical Formula: C22H30Cl2N4O6
Molecular Weight: 517.403
MDL number: MFCD00242943
EINECS: 274-619-1
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB79.20 | In Stock |
|
| 50MG | RMB188.80 | In Stock |
|
| 250MG | RMB582.40 | In Stock |
|
| 1g | RMB1457.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 203-205 C |
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone. |
| form | Solid |
| color | Dark Blue to Black |
| Water Solubility | Soluble to 5 mM in water and to 75 mM in DMSO |
| InChI | InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H |
| InChIKey | ZAHQPTJLOCWVPG-UHFFFAOYSA-N |
| SMILES | C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1.[H]Cl.[H]Cl |
| CAS DataBase Reference | 70476-82-3(CAS DataBase Reference) |
| EPA Substance Registry System | Mitoxantrone hydrochloride (70476-82-3) |
Description and Uses
Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.
Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H340-H360 |
| Precautionary statements | P201-P280-P308+P313 |
| Hazard Codes | T,T+ |
| Risk Statements | 46-61-26/27/28 |
| Safety Statements | 53-36/37/39-45-22 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | CB5748500 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29146100 |
| Hazardous Substances Data | 70476-82-3(Hazardous Substances Data) |
