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A6666212

Paclitaxel , 99% , 33069-62-4

Synonym(s):
Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL;O-De[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]paclitaxel;Paclitaxel;TAXOL InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester

CAS NO.:33069-62-4

Empirical Formula: C47H51NO14

Molecular Weight: 853.92

MDL number: MFCD00869953

EINECS: 608-826-9

Pack Size Price Stock Quantity
10MG RMB74.40 In Stock
50MG RMB160.80 In Stock
250MG RMB378.40 In Stock
1G RMB972.80 In Stock
5G RMB1983.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 213 °C (dec.)(lit.)
alpha  D20 -49° (methanol)
Boiling point: 774.66°C (rough estimate)
Density  0.200
refractive index  -49 ° (C=1, MeOH)
Flash point: 9℃
storage temp.  2-8°C
solubility  methanol: 50 mg/mL, clear, colorless
form  powder
pka 11.90±0.20(Predicted)
color  white
Water Solubility  0.3mg/L(37 ºC)
λmax 227nm(MeOH)(lit.)
Merck  14,6982
BRN  1420457
Stability: Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey RCINICONZNJXQF-MZXODVADSA-N
LogP 3.950 (est)

Description and Uses

Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer. Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death. The supply of paclitaxel is limited by its low natural abundance and currently it is being manufactured by a semi-synthetic route from deacetylbaccatin Ⅲ that is isolated from the needles of the yew tree. Recent completion of two total syntheses of taxol conquered the structural complexity of the title compound and may be useful in obtaining certain closely related analogs, some of which have been found to have antitumor activity. Paclitaxel has potential uses in the treatment of metastatic breast cancer, lung cancer, head and neck cancer, and malignant melanoma.

Paclitaxel is an antineoplastic that used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It is also used in the study of structure and function of microtubles into tubulin.

Safety

Symbol(GHS) 
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H317-H318-H334-H335-H340-H360D-H372
Precautionary statements  P202-P260-P280-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xn
Risk Statements  37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements  22-26-36/37/39-45
RIDADR  1544
WGK Germany  3
RTECS  DA8340700
10-21
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329990
Toxicity LD50 intraperitoneal in mouse: 128mg/kg

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