Medroxyprogesterone acetate , ≥98% , 71-58-9

Synonym(s):
17α-Acetoxy-6α-methylprogesterone;17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione 17-acetate;6α-Methyl-17α-acetoxyprogesterone;6α-Methyl-17α-hydroxyprogesterone acetate;Medroxyprogesterone 17-acetate

CAS NO.：71-58-9

Empirical Formula: C24H34O4

Molecular Weight: 386.52

MDL number: MFCD00010483

EINECS: 200-757-9

PRODUCT Properties

• Melting point: 206-207 °C(lit.)
• alpha: D +61° (in chloroform)
• Boiling point: 432.7°C (rough estimate)
• Density: 1.0346 (rough estimate)
• refractive index: 48 ° (C=1, Dioxane)
• storage temp.: Sealed in dry,2-8°C
• solubility: Practically insoluble in water, freely soluble in methylene chloride, soluble in acetone, sparingly soluble in ethanol (96 per cent)
• form: Solid
• color: White
• Water Solubility: <0.1 g/100 mL at 23 ºC
• Merck: 13,5817
• BRN: 2066112
• BCS Class: 2,3,1
• Stability: Stable, but weakly air and light sensitive. Incompatible with strong oxidizing agents.

Description and Uses

Medroxyprogesterone Acetate, also known as Medroxyprogesterone 17-acetate or MPA, is a synthetic progestogen and a steroidal progestin. It is derived from the human hormone progesterone. It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation. Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus. It also has anti-androgenic activity in rats, decreasing plasma testosterone levels via induction of hepatic testosterone reductase activity. Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts. Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.

Medroxyprogesterone Acetate is a synthetic progesterone receptor agonist that is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H351-H413
• Precautionary statements: P201-P202-P273-P280-P308+P313-P405
• Hazard Codes: Xn
• Risk Statements: 40-48
• Safety Statements: 22-36/37/39-45
• WGK Germany: 3
• RTECS: TU5010000
• HS Code: 29372390