ProClin8020preservatives , 122-99-6

Synonym(s):
PHE;2-Phenoxyethanol;PhG;Ethylene glycol monophenyl ether;DOWANOL EPh

CAS NO.：122-99-6

Empirical Formula: C8H10O2

Molecular Weight: 138.16

MDL number: MFCD00046644

EINECS: 204-589-7

PRODUCT Properties

• Melting point: 11-13 °C (lit.)
• Boiling point: 247 °C (lit.)
• Density: 1.102 g/mL at 25 °C (lit.)
• vapor density: 4.8 (vs air)
• vapor pressure: 0.01 mm Hg ( 20 °C)
• FEMA: 4620 | 2-PHENOXYETHANOL
• refractive index: n20/D 1.539
• Flash point: >230 °F
• storage temp.: Store below +30°C.
• solubility: soluble, clear, colorless to very faintly yellow
• pka: 14.36±0.10(Predicted)
• form: Liquid
• color: Clear colorless
• Specific Gravity: 1.109 (20/4℃)
• Odor: Faint aromatic odor
• PH Range: 7 at 10 g/l at 23 °C
• PH: 7 (10g/l, H2O, 23℃)
• explosive limit: 1.4-9.0%(V)
• Odor Type: floral
• Water Solubility: 30 g/L (20 ºC)
• Merck: 14,7257
• BRN: 1364011
• InChIKey: QCDWFXQBSFUVSP-UHFFFAOYSA-N
• LogP: 1.2 at 23℃
• CAS DataBase Reference: 122-99-6(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenoxyethanol(122-99-6)
• EPA Substance Registry System: Ethylene glycol monophenyl ether (122-99-6)

Description and Uses

Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H319
• Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36-R36-R22
• Safety Statements: 26-S26
• WGK Germany: 1
• RTECS: KM0350000
• Autoignition Temperature: 535 °C DIN 51794
• Hazard Note: Irritant
• TSCA: Yes
• HS Code: 29094990
• Hazardous Substances Data: 122-99-6(Hazardous Substances Data)
• Toxicity: LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg