(Methylamino)acetaldehyde dimethyl acetal , 97% , 122-07-6
Synonym(s):
(Methylamino)acetaldehyde dimethyl acetal;1,1-Dimethoxy-2-methylaminoethane;2,2-Dimethoxy-N-methylethylamine
CAS NO.：122-07-6
Empirical Formula: C5H13NO2
Molecular Weight: 119.16
MDL number: MFCD00008485
EINECS: 204-520-0
| Pack Size | Price | Stock | Quantity |
| 5g | RMB36.00 | In Stock |
|
| 25G | RMB71.20 | In Stock |
|
| 100G | RMB220.00 | In Stock |
|
| 500G | RMB994.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | -73°C |
| Boiling point: | 140 °C (lit.) |
| Density | 0.928 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 85 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | liquid &_& neat |
| pka | 8.29±0.20(Predicted) |
| color | Colorless to Light yellow to Light orange |
| PH | 10.9 (10g/l, H2O, 20℃) |
| Water Solubility | miscible |
| Sensitive | Air Sensitive |
| BRN | 605322 |
Description and Uses
Methylaminoacetaldehyde dimethyl acetal can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole, the chemical name is 1-methylimidazole-2-thiol, which is an antithyroid drug, and its mechanism of action is to inhibit thyroid endoperoxide Enzymes, thereby hindering the oxidation of iodide absorbed into the thyroid and the coupling of tyrosine, hindering the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have observed that B lymphocytes synthesize antibodies, reduce the level of thyroid-stimulating antibodies in the blood circulation, and restore the suppressor T cells to normal.
(Methylamino)acetaldehyde dimethyl acetal can be used as a reactant to synthesize:
- Aza[3.3.2] cyclazines by reacting with 5-methyloxazolo[3,2-a]pyridinium salts via synthesis of functionalized 5-aminoindolizines intermediates.
- N-(2,2-Dimethoxyethyl)-N-methyl-3,4-dimethoxyphenylglycine by Petasis reaction with glyoxylic acid and 3,4-dimethoxyphenylboronic acid.
- Substituted imidazoles via copper-catalyzed reaction with various nitriles.
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Warning |
| Hazard statements | H226-H319-H335 |
| Precautionary statements | P210-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 10-36-36/37/38 |
| Safety Statements | 26-36-37/39-16 |
| RIDADR | UN 1989 3/PG 3 |
| WGK Germany | 3 |
| F | 2-10 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29225000 |
