Lumefantrine , >98.0%(HPLC) , 82186-77-4

Synonym(s):
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol;Benflumetol;CPG-56695;Lumefantrine

CAS NO.：82186-77-4

Empirical Formula: C30H32Cl3NO

Molecular Weight: 528.94

MDL number: MFCD05662268

EINECS: 617-303-4

PRODUCT Properties

• Melting point: 129-131°C
• Boiling point: 642.5±55.0 °C(Predicted)
• Density: 1.252
• storage temp.: 15-25°C
• solubility: DMSO: ≥20mg/mL
• pka: 13.44±0.20(Predicted)
• form: powder
• color: yellow
• Merck: 14,5597
• CAS DataBase Reference: 82186-77-4(CAS DataBase Reference)

Description and Uses

Lumefantrine is a derivative of halofantrine that has been reported to exhibit antimalarial activity when combined with artemether in the treatment of multidrug-resistant Plasmodium falciparium . No evidence of cardiotoxicity has been reported with this combination, which may offer promise for successful treatment of resistant organisms.

Lumefantrine has been used:
to study its effect on ex-vivo?Plasmodium falciparum?sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi?growth inhibition studies

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• HS Code: 29221950
• Hazardous Substances Data: 82186-77-4(Hazardous Substances Data)