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A5295112

Lansoprazole , ≥98% , 103577-45-3

Synonym(s):
2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl] methyl] sulfinyl]-1H-benzimidazole;LAN;Lansoprazole

CAS NO.:103577-45-3

Empirical Formula: C16H14F3N3O2S

Molecular Weight: 369.36

MDL number: MFCD00866873

EINECS: 2017-001-1

Pack Size Price Stock Quantity
250MG RMB42.40 In Stock
1G RMB45.60 In Stock
5G RMB92.80 In Stock
25G RMB351.20 In Stock
100G RMB1342.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 178-182°C dec.
Boiling point: 555.8±60.0 °C(Predicted)
Density  1.50±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in anhydrous ethanol, very slightly soluble in acetonitrile.
pka pKa 2.34±0.37 (Occasionally);3.53±0.37 (Occasionally);8.48±0.30 (Occasionally)
form  powder
color  off-white
Merck  14,5362
BCS Class 2
InChIKey MJIHNNLFOKEZEW-UHFFFAOYSA-N
CAS DataBase Reference 103577-45-3(CAS DataBase Reference)

Description and Uses

Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase. It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 μM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 μM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH. It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion. Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  DD9487500
HS Code  29339900
Hazardous Substances Data 103577-45-3(Hazardous Substances Data)
Toxicity dog,LD,oral,> 2gm/kg (2000mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 387, 1993.

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