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A5289912

Linezolid , ≥99% , 165800-03-3

Synonym(s):
Linezolid;N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide;PNU-100766;U-100766

CAS NO.:165800-03-3

Empirical Formula: C16H20FN3O4

Molecular Weight: 337.35

MDL number: MFCD00937825

EINECS: 605-416-1

Pack Size Price Stock Quantity
10MG RMB31.20 In Stock
50MG RMB39.20 In Stock
100mg RMB47.20 In Stock
250MG RMB55.20 In Stock
1G RMB63.20 In Stock
5G RMB295.20 In Stock
25G RMB1199.20 In Stock
100g RMB3199.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 176-1780C
alpha  D20 -9° (c = 0.919 in chloroform)
Boiling point: 585.5±50.0 °C(Predicted)
Density  1.302±0.06 g/cm3(Predicted)
storage temp.  room temp
solubility  DMSO: >20mg/mL
pka 15.53±0.46(Predicted)
form  powder
color  white to off-white
BCS Class 4
InChIKey TYZROVQLWOKYKF-ZDUSSCGKSA-N
CAS DataBase Reference 165800-03-3(CAS DataBase Reference)

Description and Uses

Linezolid reached the US market for the treatment of patients with infections caused by serious Gram-positive pathogens, particularly skin and soft tissue infections, communityacquired pneumonia and vancomycin-resistant enterococcal infections. Linezolid is the (S)-enantiomer of an oxazolidin-2-one synthesized in a multistep process from 3,4- difluoronitrobenzene, the key step being the cyclization of a carbamate, using a chiral epoxyester, into an enantiomerically pure oxazolidin-2-one. Linezolid can be considered as the first of a new class of antibacterial agents known as oxazolidinones, its mechanism of action being related to the inhibition of early ribosomal protein synthesis without directly inhibiting DNA or RNA synthesis. In vitro studies demonstrated that linezolid was effective, at potency levels similar to vancomycin, against staphylococcal, streptococcal and pneumococcal infections (MIC values in the range of 0.5 to 2 μg/ml), enterococcal species including VRE and VSE (MIC values about 4 μg/ml), but also other vancomycin-resistant bacteria. Linezolid is rapidly absorbed orally, its bioavailability is nearly complete at 250 mg dose giving a Cmax to MIC ratio sufficient to have pathogenic strain eradication in the clinical setting. It is considered that this new promising agent may offer new options for therapy of multi-drug infections.

Prototype of the oxazolidinone antimicrobials; inhibits bacterial mRNA translation.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H372
Precautionary statements  P260
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36-24/25
WGK Germany  3
RTECS  AC2720000
HS Code  29419000
Hazardous Substances Data 165800-03-3(Hazardous Substances Data)

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