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A5289312

Lesinurad , 98% , 878672-00-5

CAS NO.:878672-00-5

Empirical Formula: C17H14BrN3O2S

Molecular Weight: 404.28

MDL number:

EINECS: 689-245-8

Pack Size Price Stock Quantity
5MG RMB199.20 In Stock
10MG RMB319.20 In Stock
25mg RMB639.20 In Stock
50MG RMB999.20 In Stock
100mg RMB1599.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >171oC (dec.)
Boiling point: 643.7±65.0 °C(Predicted)
Density  1.72±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly, Heated)
pka 2.91±0.10(Predicted)
form  Solid
color  White to Off-White

Description and Uses

Approved by the FDA late in 2015, lesinurad is an urate anion exchange transporter 1 (URAT1) inhibitor for use in the treatment of gout. Ardea Biosciences, which is a subsidiary of AstraZeneca, developed lesinurad to be used in a combination therapy with xanthine oxidase inhibitors for the treatment of hyperuricaemia associated with gout. The approval process is ongoing in several other countries across the globe, with the EMA Committee for Medicinal Products for Human Use giving lesinurad a positive opinion for use as an adjunctive therapy in combination with xanthine oxidase inhibitors to treat hyperuricaemia.

Lesinurad is used to synthesize febuxostat which is a non-purine analog inhibitor of xanthine oxidase. Febuxostat is approved by the European Medicines Agency and the US Food and Drug Administration for treating gout.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

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