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A5262312

Lovastatin , Analysis of standard products, ≥98% , 75330-75-5

Synonym(s):
2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid;6-α-Methylcompactin;Lovastatin;Mevinolin;Monacolin K

CAS NO.:75330-75-5

Empirical Formula: C24H36O5

Molecular Weight: 404.54

MDL number: MFCD00072164

EINECS: 616-212-7

Pack Size Price Stock Quantity
20MG RMB78.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 175°C
alpha  D25 +323° (c = 0.5 g in 100 ml acetonitrile)
Boiling point: 559.2±50.0 °C(Predicted)
Density  1.12±0.1 g/cm3(Predicted)
vapor pressure  0Pa at 25℃
refractive index  320 ° (C=0.5, CH3CN)
storage temp.  -20°C
solubility  ethanol: soluble9.80-10.20mg/mL, clear, colorless to faintly yellow
pka 13.49±0.40(Predicted)
form  White to off-white powder
color  White
Water Solubility  0.0004 mg/mL at 25 ºC
Merck  14,5586
BCS Class 2
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
LogP 4.260

Description and Uses

Lovastatin is an orally-active hypocholesterolemic useful in the treatment of familial hypercholesterolemia. The drug acts by inhibiting the HMG-CoA reductase-catalyzed rate limiting step of cholesterol biosynthesis. While treatment with lovastatin leads to significant reductions in total and LDL cholesterol, its effect on atherosclerosis or coronary heart disease has not been established.

Cardiovascular

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H351-H361f
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37/39-26
RIDADR  3077
WGK Germany  3
RTECS  EK7907000
HazardClass  9
PackingGroup  III
HS Code  29322090
Toxicity LD50 orally in mice: >1000 mg/kg (Endo)

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