Lycorine hydrochloride , ≥98%(HPLC) , 2188-68-3
Synonym(s):
Licorin hydrochloride;Lychorine chloride;Lycorine HCl
| Pack Size | Price | Stock | Quantity |
| 1G | RMB307.20 | In Stock |
|
| 5G | RMB653.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 206 °C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in water (15 mg/ml) |
| form | powder |
| color | White to off-white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month. |
Description and Uses
Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Lycorine Hydrochloride is the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
