PRODUCT Properties
| Melting point: | 278° |
| alpha | D15 +352° (acetone); D +440° (chloroform) |
| Boiling point: | 444.29°C (rough estimate) |
| Density | 1.1684 (rough estimate) |
| refractive index | 1.5900 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| form | Off-white to light yellow solid. |
| pka | 17.27±0.20(Predicted) |
| color | Yellow |
| Odor | Odorless |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| InChIKey | TXDUTHBFYKGSAH-UHFFFAOYSA-N |
| LogP | 3.888 (est) |
| CAS DataBase Reference | 518-17-2(CAS DataBase Reference) |
Description and Uses
Evodiamine (518-17-2) is a quinolone alkaloid isolated from Evodia rutaecarpa.1 Evodia Rutaecarpa is a very popular herb used in traditional chinese medicine to treat a variety of ailments. Evodiamine has been shown to elicit a variety of biological effects including induction of apoptosis, inhibiting cancer cell proliferation, promoting cell cycle arrest in G2/M, inhibiting invasion and metastasis of cancer cells, inhibiting angiogenesis, induction of oxidative stress and subsequent apoptosis and inhibition of NF-κB.2 It also functions as an activator of TRPV1 (EC50 = 1.03 μM)3 and acts as an anti-inflammatory agent4.
A chemical extracted from Evodia plants, and has been shown to reduce fat uptake.
