Home Categories Chemical Reagents α-Ketoglutaric acid
A5233612

α-Ketoglutaric acid , 98% , 328-50-7

Synonym(s):
2-Ketoglutaric acid;2-Oxoglutaric acid;2-Oxopentanedioic acid;alpha-Ketoglutarate;alpha-Ketoglutaric acid

CAS NO.:328-50-7

Empirical Formula: C5H6O5

Molecular Weight: 146.1

MDL number: MFCD00004165

EINECS: 206-330-3

Pack Size Price Stock Quantity
25G RMB24.00 In Stock
100G RMB64.00 In Stock
500G RMB267.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 113-115 °C
Boiling point: 185.67°C (rough estimate)
Density  1.2821 (rough estimate)
vapor pressure  0.01Pa at 25℃
refractive index  1.3920 (estimate)
FEMA  3891 | 2-OXOPENTANEDIOIC ACID
storage temp.  2-8°C
solubility  H2O: soluble0.1g/mL, clear, colorless
form  Crystalline Powder
pka 2.47(at 25℃)
color  White to slightly yellow
Odor Odorless
PH 3.09(1 mM solution);2.36(10 mM solution);1.77(100 mM solution)
Water Solubility  Soluble in water, methanol and dimethyl sulfoxide.
Merck  14,5303
JECFA Number 634
BRN  1705689
InChIKey KPGXRSRHYNQIFN-UHFFFAOYSA-N
LogP -2.08 at 25℃

Description and Uses

2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.

2-Ketoglutaric acid has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries. It is used as an intermediate in the kreb's cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. It is also used in dietary supplements to improve protein synthesis.

Safety

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338+P310
Hazard Codes  Xi,T
Risk Statements  37/38-41-36/37/38-23/24/25
Safety Statements  26-39-45-36/37/39
WGK Germany  3
TSCA  Yes
HS Code  29183000

RELATED PRODUCTS