N,N'-Carbonyldiimidazole , 99% , 530-62-1

Synonym(s):
1,1′-Carbonyldiimidazole;1,1′-Carbonyl-diimidazole;CDI

CAS NO.：530-62-1

Empirical Formula: C7H6N4O

Molecular Weight: 162.15

MDL number: MFCD00005286

EINECS: 208-488-9

PRODUCT Properties

• Melting point: 117-122 °C(lit.)
• Boiling point: 288.83°C (rough estimate)
• Density: 1.303 g/mL at 25 °C
• vapor pressure: 0.006-0.012Pa at 20-25℃
• refractive index: n20/D1.434
• storage temp.: 2-8°C
• solubility: Soluble in dimethylformamide.
• form: Crystalline Powder
• pka: 2.90±0.10(Predicted)
• color: White to light cream
• PH Range: 7.7 at 50 g/l
• PH: 7.7 (50g/l, H2O, 20℃)
• Water Solubility: Insoluble in water
• Sensitive: Moisture Sensitive
• Merck: 14,1819
• BRN: 6826
• Stability: Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.
• InChIKey: PFKFTWBEEFSNDU-UHFFFAOYSA-N
• CAS DataBase Reference: 530-62-1(CAS DataBase Reference)
• EPA Substance Registry System: 1H-Imidazole, 1,1'-carbonylbis- (530-62-1)

Description and Uses

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

Safety

• Symbol(GHS): GHS05,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H314-H360D
• Precautionary statements: P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: C,Xi,Xn
• Risk Statements: 22-34-36/37/38-40-36/38
• Safety Statements: 26-36/37/39-45-37/39-27-36/37
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 2
• F: 10-21
• Hazard Note: Harmful/Corrosive/Moisture Sensitive
• TSCA: T
• HazardClass: 8
• PackingGroup: III
• HS Code: 29332990
• Toxicity: LD50 orally in Rabbit: 1071 mg/kg