Kanamycin sulfate , USPGrade, derived from Kanamycin chain mold , 25389-94-0

Synonym(s):
Kamycin;Kanamycin A;Kanamycin sulfate from Streptomyces kanamyceticus;Kanamycin sulfate salt;Kanamycin A

CAS NO.：25389-94-0

Empirical Formula: C18H38N4O15S

Molecular Weight: 582.58

MDL number: MFCD00070253

EINECS: 246-933-9

PRODUCT Properties

• Melting point: 250°C
• alpha: +112～+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)
• Density: 1.3619 (rough estimate)
• refractive index: 117.5 ° (C=1, H2O)
• storage temp.: 2-8°C
• solubility: H₂O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
• form: powder
• color: white to off-white
• PH Range: 6.5 - 8.5 (1% solution)
• Water Solubility: Soluble in water at 10mg/ml
• Merck: 14,5281
• InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N

Description and Uses

Kanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.

Kanamycin sulfate is an antibacterial agent similar to neomycin.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360D
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: T
• Risk Statements: 61
• Safety Statements: 22-24/25-45-53
• WGK Germany: 3
• RTECS: NZ3225030
• HS Code: 29419020
• Toxicity: LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)