Home Categories Biochemical Engineering Ivabradine HCl
A5040712

Ivabradine HCl , ≥98% , 148849-67-6

Synonym(s):
3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

CAS NO.:148849-67-6

Empirical Formula: C27H36N2O5.HCl

Molecular Weight: 505.05

MDL number: MFCD00929899

EINECS: 638-798-3

Pack Size Price Stock Quantity
250MG RMB153.60 In Stock
1G RMB494.64 In Stock
5g RMB1516.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 193-196?C
alpha  58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp.  2-8°C
solubility  H2O: ≥5mg/mL (warmed)
form  powder
color  white to beige
optical activity [α]/D +5 to +9°, c = 1 in DMSO
Merck  14,5247
InChIKey HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
CAS DataBase Reference 148849-67-6(CAS DataBase Reference)

Description and Uses

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

angina therapeutic

Safety

Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H400
Precautionary statements  P273
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  2933.79.1500

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