IWR-1-endo , ≥98% , 1127442-82-3
Synonym(s):
Inhibitor of Wnt Response-1, TNKS1/2 Inhibitor II, Tankyrase1/2 Inhibitor II, Wnt Pathway Inhibitor I;4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide;InSolution Wnt Antagonist I, IWR-1-endo - CAS 1127442-82-3 - Calbiochem;IWR1
CAS NO.：1127442-82-3
Empirical Formula: C25H19N3O3
Molecular Weight: 409.44
MDL number: MFCD18086875
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB296.80 | In Stock |
|
| 10MG | RMB532.00 | In Stock |
|
| 50MG | RMB2386.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| alpha | -3.0～+3.0°(20℃/D)(c=0.1,CH3CN) |
| Boiling point: | 643.9±55.0 °C(Predicted) |
| Density | 1.425±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble5mg/mL, clear |
| pka | 11.88±0.43(Predicted) |
| form | Liquid |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Description and Uses
IWR-1 endo (1127442-82-3) is a potent inhibitor of Wnt signaling (IC50=180 nM).1?Inhibits zebrafish tailfin regeneration (0.5 mM).2?Acts via inhibition of tankyrase and attenuates Wnt/β-catenin signaling in cancer stem-like cells.3?Promotes self-renewal and maintains pluripotency of human embryonic stem cells.4?Promotes differentiation of pluripotent stem cells into cardiomyocytes.5
IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
