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A5006712

Imazalil solution , analyticalstandard,100ug/mlinmethanol , 35554-44-0

Synonym(s):
1-[2-(Allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole;Imazalil

CAS NO.:35554-44-0

Empirical Formula: C14H14Cl2N2O

Molecular Weight: 297.18

MDL number: MFCD00055331

EINECS: 252-615-0

Pack Size Price Stock Quantity
1ML RMB143.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 52.7°C
Boiling point: >340°C
Density  1.348
vapor pressure  1.58 x l0-4 Pa (20 °C)
refractive index  1.5680 (estimate)
storage temp.  2-8°C
solubility  Chloroform: Slightly Soluble; Methanol: Slightly Soluble
form  Solid
pka 6.53 (weak base)
color  Light yellow to yellow
Water Solubility  0.018 g/100 mL
Merck  13,3616
BRN  545683
InChIKey PZBPKYOVPCNPJY-UHFFFAOYSA-N
LogP 3.820

Description and Uses

Imazalil is an imidazole fungicide that inhibits ergosterol biosynthesis. Imazalil inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7). It inhibits S. cerevisiae, but not rat liver microsomal, cytochrome P450 enzymes (CYPs; IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM). Imazalil activates the murine pregnane X receptor (PXR) in a concentration-dependent manner in a cell-based reporter assay. It increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice when administered at a dose of 100 mg/kg. Imazalil also increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the murine constitutive androstane receptor (mCAR) agonist TCPOBOP . Formulations containing imazalil have been used to control fungal infection in agriculture.

antifungal

Safety

Symbol(GHS) 
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H301-H318-H332-H410
Precautionary statements  P261-P273-P280-P301+P310-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,N
Risk Statements  20/22-41-50/53
Safety Statements  26-39-60-61
RIDADR  2588
WGK Germany  3
RTECS  NI4776000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29332900

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