Chlorpheniramine Maleate , ≥99% , 113-92-8
Synonym(s):
(±)-Chlorpheniramine maleate salt;Chlorpheniramine maleate solution
CAS NO.:113-92-8
Empirical Formula: C20H23ClN2O4
Molecular Weight: 390.86
MDL number: MFCD00069225
EINECS: 204-037-5
Pack Size | Price | Stock | Quantity |
5G | RMB41.60 | In Stock |
|
25G | RMB67.20 | In Stock |
|
100G | RMB203.20 | In Stock |
|
500G | RMB711.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 130-135 °C (lit.) |
alpha | -1~+1°(D/20℃)(c=5,DMF) |
Density | 1.1984 (rough estimate) |
refractive index | 1.6800 (estimate) |
Flash point: | 9℃ |
storage temp. | 2-8°C |
solubility | Freely soluble in water, soluble in ethanol (96 per cent) |
form | Solid |
color | White to Almost white |
Odor | odorless |
PH | 4.0~5.5 (10g/l, 25℃) |
Water Solubility | 1-5 g/100 mL at 21 ºC |
Merck | 14,2180 |
BCS Class | 3/1 |
InChIKey | DBAKFASWICGISY-BTJKTKAUSA-N |
LogP | 3.389 (est) |
EPA Substance Registry System | Chlorpheniramine maleate (113-92-8) |
Description and Uses
Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.
(±)-Chlorpheniramine maleate salt has been used:
- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301+P312+P330 |
Hazard Codes | T,F |
Risk Statements | 25-39/23/24/25-23/24/25-11 |
Safety Statements | 36/37/39-45-36/37-16 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | US6504000 |
TSCA | Yes |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 29333990 |
Toxicity | LD50 orally in mice: 162 mg/kg (Smith) |