Chlorpheniramine Maleate , ≥99% , 113-92-8
Synonym(s):
(±)-Chlorpheniramine maleate salt;Chlorpheniramine maleate solution
CAS NO.：113-92-8
Empirical Formula: C20H23ClN2O4
Molecular Weight: 390.86
MDL number: MFCD00069225
EINECS: 204-037-5
| Pack Size | Price | Stock | Quantity |
| 5G | RMB41.60 | In Stock |
|
| 25G | RMB67.20 | In Stock |
|
| 100G | RMB203.20 | In Stock |
|
| 500G | RMB711.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 130-135 °C (lit.) |
| alpha | -1～+1°(D/20℃)(c=5,DMF) |
| Density | 1.1984 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, soluble in ethanol (96 per cent) |
| form | Solid |
| color | White to Almost white |
| Odor | odorless |
| PH | 4.0～5.5 (10g/l, 25℃) |
| Water Solubility | 1-5 g/100 mL at 21 ºC |
| Merck | 14,2180 |
| BCS Class | 3/1 |
| InChIKey | DBAKFASWICGISY-BTJKTKAUSA-N |
| LogP | 3.389 (est) |
Description and Uses
Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.
(±)-Chlorpheniramine maleate salt has been used:
- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | T,F |
| Risk Statements | 25-39/23/24/25-23/24/25-11 |
| Safety Statements | 36/37/39-45-36/37-16 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | US6504000 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29333990 |
| Toxicity | LD50 orally in mice: 162 mg/kg (Smith) |
