Isopentyl nitrite , AR,90% , 110-46-3
Synonym(s):
Isoamyl nitrite;iso-Amyl nitrite, iso-Pentyl nitrite, Nitrous acid isoamyl ester;Isopentyl nitrite
CAS NO.：110-46-3
Empirical Formula: C5H11NO2
Molecular Weight: 117.15
MDL number: MFCD00002057
EINECS: 203-770-8
PRODUCT Properties
| Boiling point: | 99 °C(lit.) |
| Density | 0.872 g/mL at 25 °C(lit.) |
| vapor pressure | 35-59.995hPa at 20-25℃ |
| refractive index | n |
| Flash point: | 50 °F |
| storage temp. | Store at +15°C to +25°C. |
| solubility | Chloroform (Soluble), Methanol (Slightly) |
| form | Liquid |
| color | Clear yellow |
| Water Solubility | <0.01 g/100 mL at 18 ºC |
| Sensitive | Air & Light Sensitive |
| Merck | 14,5123 |
| BRN | 969510 |
| Stability: | Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents. |
| InChIKey | OWFXIOWLTKNBAP-UHFFFAOYSA-N |
| LogP | 2.45-2.85 |
| CAS DataBase Reference | 110-46-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Amyl Nitrite(110-46-3) |
| EPA Substance Registry System | Isoamyl nitrite (110-46-3) |
Description and Uses
Amyl nitrite had been used clinically as early as 1867, when the Scottish physician Sir Thomas Brunton used it as a vasodilator as treatment for angina pectoris in his patients. In the late 1880s, a protective effect on cyanide toxicity in canines was noted when amyl nitrite was inhaled postexposure. Amyl nitrite has been used clinically in a multicomponent cyanide antidote kit and is also a recreational drug of abuse (‘poppers’).
Isoamyl nitrite is a light yellow, transparent liquid with a
pleasant, fragrant, fruity odor. Amyl nitrite was introduced to
medicine in 1859 and has been under considerable pharmacological
investigation since that time. Its major use was for
treating angina pectoris through its vasodilative effect on the
coronary arteries. However, this effect is transient, and
nitroglycerin and longer acting nitrates have largely replaced
it. Amyl nitrite has been most helpful in clarifying the
differential diagnosis of murmurs. For example, left ventricular
outflowobstruction increases followingamyl nitrite administration.
Mitral regurgitation decreases following amyl nitrite
as does the apical diastolic rumble of mitral stenosis. The
Austin–Flint rumble decreases followingamyl nitrite as does a
ventricular septal defect and acyanotic tetralogy of Fallot. Pulmonic stenosis increases as does isolated valvular pulmonary
stenosis following amyl nitrite.
Isoamyl nitrite has also been reportedly used for inhalation
abuse. The symptoms following inhalation of
large doses by humans are flushing of the face, pulsatile
headache, disturbing tachycardia, cyanosis (methemoglobinemia),
weakness, confusion, restlessness, faintness, and
collapse, particularly if the individual is standing. The
symptoms are usually of short duration. Industrial intoxication
has not been reported.
Safety
| Symbol(GHS) |     GHS02,GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H302+H332-H314-H317-H341 |
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-20/22 |
| Safety Statements | 16-24-46 |
| RIDADR | UN 1113 3/PG 2 |
| WGK Germany | 1 |
| RTECS | NT0187500 |
| F | 1-8-9 |
| Autoignition Temperature | 208 °C |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29209090 |
| Hazardous Substances Data | 110-46-3(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 505 mg/kg |
