6-(5H)-Phenanthridinone , ≥98.0%(HPLC) , 1015-89-0

Synonym(s):
NSC 11021;NSC 40943;NSC 61083

CAS NO.：1015-89-0

Empirical Formula: C13H9NO

Molecular Weight: 195.22

MDL number: MFCD00004988

EINECS: 213-804-3

PRODUCT Properties

• Melting point: 290-292 °C(lit.)
• Boiling point: 435 °C
• Density: 1.230±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL
• form: powder to crystal
• pka: 13.27±0.20(Predicted)
• color: White to Light yellow to Light orange
• Water Solubility: Soluble in DMSO (5 mg/ml). Insoluble in water.
• λmax: 338nm(EtOH)(lit.)
• BRN: 140641
• CAS DataBase Reference: 1015-89-0(CAS DataBase Reference)
• NIST Chemistry Reference: 6(5H)-phenanthridinone(1015-89-0)
• EPA Substance Registry System: 6-Phenanthridinone (1015-89-0)

Description and Uses

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: SG0370000
• HS Code: 29337900