Home Categories 5-Cholesten-3β-ol-7-one
A4770112

5-Cholesten-3β-ol-7-one , >99% , 566-28-9

Synonym(s):
3β-Hydroxy-5-cholesten-7-one;7-Ketocholesterol;7-oxocholesterol; 7-oxo-5-cholesten-3β-ol-7-one; 5-cholesten-3β-ol-7-one; 3β-hydroxycholest-5-en-7-one; 110806

CAS NO.:566-28-9

Empirical Formula: C27H44O2

Molecular Weight: 400.65

MDL number: MFCD00010474

Pack Size Price Stock Quantity
5MG RMB663.20 In Stock
25MG RMB2879.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 158-160°C
Boiling point: 463.26°C (rough estimate)
Density  1.0044 (rough estimate)
refractive index  1.4480 (estimate)
storage temp.  room temp
solubility  Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 14.68±0.70(Predicted)
color  Crystals from CHCl3/Et2O

Description and Uses

7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL. It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by the cytochrome P450 (CYP) isoform CYP7A1. 7-keto Cholesterol inhibits CYP7A1 (IC50 = ~1 μM). It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro. Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye. Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer''s disease, and age-related macular degeneration.

A metabolite of Cholesterol

Safety

WGK Germany  3
RTECS  FZ8708000

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