Halobetasol Propionate , ≥98% , 66852-54-8

CAS NO.：66852-54-8

Empirical Formula: C25H31ClF2O5

Molecular Weight: 484.96

MDL number: MFCD00866013

EINECS: 686-247-0

PRODUCT Properties

• Melting point: 213-215°C
• Boiling point: 570.7±50.0 °C(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)
• storage temp.: Refrigerator
• solubility: Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 12.55±0.70(Predicted)
• color: White to Off-White
• InChIKey: BDSYKGHYMJNPAB-QNGYMBKVNA-N
• SMILES: O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,9,17,19,21,24,r|
• CAS DataBase Reference: 66852-54-8(CAS DataBase Reference)

Description and Uses

Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.  It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.

Halobetasol propionate is a corticosteroid (cortisone-like medicine or steroid). As an anti-inflammatory drug, halobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by certain skin conditions. It is also used to treat plaque psoriasis.This medicine is available only with doctor's prescription.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H372-H341-H361
• Precautionary statements: P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501
• HS Code: 2937220000