1-Hydroxypyridine-2-thione zinc salt , 96% , 13463-41-7
Synonym(s):
Mercaptopyridine N-oxide zinc salt;Pyrithione
CAS NO.：13463-41-7
Empirical Formula: C10H8N2O2S2Zn
Molecular Weight: 317.7
MDL number: MFCD00067336
EINECS: 236-671-3
| Pack Size | Price | Stock | Quantity |
| 5g | RMB24.00 | In Stock |
|
| 25G | RMB46.40 | In Stock |
|
| 100G | RMB128.00 | In Stock |
|
| 500G | RMB416.80 | In Stock |
|
| 2.5kg | RMB1440.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | approximate 240℃ |
| Density | 1.782 g/cm3(Temp: 25 °C) |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | almost transparency in Pyridine |
| form | Powder |
| color | White to Orange to Green |
| Odor | Mild Characteristic |
| Water Solubility | Insoluble (<0.1 g/100 mL at 21 ºC) |
| Merck | 14,7994 |
| InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2 |
| InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| SMILES | C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-] |
| LogP | 0.9 at 25℃ and pH7.5-7.7 |
| Surface tension | 73mN/m at 7.22mg/L and 20℃ |
Description and Uses
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.
Safety
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H301-H318-H330-H360D-H372-H410 |
| Precautionary statements | P202-P260-P273-P280-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T+,N,T |
| Risk Statements | 24/25-26-37/38-41-50/53-23-22 |
| Safety Statements | 26-28-36/37/39-45-61-60-39 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | ZH0950000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29333990 |
| Toxicity | LD50 oral in rat: 177mg/kg |
