Heptafluorobutyric anhydride , Used for GC derivatives, ≥99.0% , 336-59-4

Synonym(s):
HFAA;HFBA;Perfluorobutyric anhydride

CAS NO.：336-59-4

Empirical Formula: C8F14O3

Molecular Weight: 410.06

MDL number: MFCD00000432

EINECS: 206-410-8

PRODUCT Properties

• Melting point: −43 °C(lit.)
• Boiling point: 108-110 °C(lit.)
• Density: 1.674 g/mL at 20 °C(lit.)
• refractive index: n20/D 1.287(lit.)
• Flash point: None
• storage temp.: room temp
• solubility: Miscible with halogenated solvents. Immiscible with polar solvents.
• form: Liquid
• Specific Gravity: 1.653
• color: Colorless to Almost colorless
• Water Solubility: REACTS
• Sensitive: Hygroscopic
• BRN: 856036
• Stability: Moisture Sensitive
• InChIKey: UFFSXJKVKBQEHC-UHFFFAOYSA-N

Description and Uses

Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970).
HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.
suzuki reaction

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314
• Precautionary statements: P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
• Hazard Codes: C
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• Hazard Note: Corrosive/Hygroscopic
• TSCA: T
• HazardClass: 8
• PackingGroup: III
• HS Code: 29159080