trans-4-Hydroxy-L-proline , 99% , 51-35-4

Synonym(s):
Hyp;Hydroxyproline;4-Hydroxyproline;L(-)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid

CAS NO.：51-35-4

Empirical Formula: C5H9NO3

Molecular Weight: 131.13

MDL number: MFCD00064320

EINECS: 200-091-9

PRODUCT Properties

• Melting point: 273 °C (dec.)(lit.)
• alpha: -75.5 º (c=5, H2O)
• Boiling point: 242.42°C (rough estimate)
• Density: 1.3121 (rough estimate)
• vapor density: 4.5 (vs air)
• refractive index: -75.5 ° (C=4, H2O)
• storage temp.: Store below +30°C.
• solubility: H₂O: 50 mg/mL
• form: Crystals or Crystalline Powder
• pka: 1.82, 9.66(at 25℃)
• color: White
• Odor: Odorless
• PH: 5.5-6.5 (50g/l, H2O, 20℃)
• optical activity: [α]25/D 75.6°, c = 1 in H2O
• Water Solubility: 357.8 g/L (20 º C)
• Merck: 14,4840
• BRN: 471933
• InChIKey: PMMYEEVYMWASQN-DMTCNVIQSA-N
• LogP: -0.350 (est)

Description and Uses

A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P271-P280
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 24/25-36/37/39-27-26
• WGK Germany: 3
• RTECS: TW3586500
• TSCA: Yes
• HazardClass: IRRITANT
• HS Code: 29339990