Home Categories Organic Chemistry Hexachloroethane
A4720912

Hexachloroethane , StandardforGC,≥99.5%(GC) , 67-72-1

Synonym(s):
Hexachloroethane solution;Perchloroethane

CAS NO.:67-72-1

Empirical Formula: C2Cl6

Molecular Weight: 236.74

MDL number: MFCD00000799

EINECS: 200-666-4

Update time: 2022-07-08

PRODUCT Properties

Melting point: 183-185 °C (dec.) (lit.)
Boiling point: 186℃
Density  2.091 g/mL at 25 °C (lit.)
vapor density  8.16 (vs air)
vapor pressure  0.4 mm Hg ( 20 °C)
refractive index  1.5282 (estimate)
Flash point: 9℃
storage temp.  2-8°C
solubility  Soluble in alcohol, benzene, chloroform, ether
form  Crystals or Crystalline Powder
color  White
Water Solubility  0.05 g/L (22 ºC)
Merck  14,4679
BRN  1740341
Henry's Law Constant 1.43, 2.81, and 5.31 at 10, 20, and 30 °C, respectively (Munz and Roberts, 1987)
Exposure limits TLV-TWA 10 ppm (~100 mg/m3) (ACGIH), 1 ppm (MSHA and OSHA), Lowest Feasi ble Limit (NIOSH); carcinogenicity: Animal Limited Evidence (IARC).
Stability: Stable. Non-combustible. May react with hot metals, strong oxidizing agents.
CAS DataBase Reference 67-72-1(CAS DataBase Reference)
IARC 2B (Vol. 73) 1999
NIST Chemistry Reference Ethane, hexachloro-(67-72-1)
EPA Substance Registry System Hexachloroethane (67-72-1)

Description and Uses

Hexachloroethane (HCE) is a halogenated hydrocarbon consisting of six chlorines attached to an ethane (ACGIH, 1991); it is a white to pale yellow solid that is unstable in air and evaporates gradually. It smells like camphor when its concentration in air and water are 150 and 10 ppb, respectively. HCE itself does not catch fire easily; however; in aqueous nonbiological conditions it has been determined that HCE is unstable and nonenzymatic dechlorination in the absence of nicotinamide adenine dinucleotide phosphate (NADP) occurs. It rapidly degrades in soil or groundwater. Also, some microorganisms break down HCE without oxygen, and decomposition in aerobic conditions has been reported. Some bioconcentration of HCE in fish has been determined, though upper levels through the food chain are limited, since it is rapidly metabolized by fish, which is discussed later (ATSDR, 1997).
Eyes, skin, respiratory system, and kidneys have been proposed as main targets in humans upon exposure. Symptoms include blinking, tearing, photophobia, and irritation of eyes. Also, facial muscles may have difficulty in movement. Animal studies on effects of HCE during pregnancy are limited. After oral exposure, HCE is primarily distributed to fat tissue. Toxicokinetic studies in animals indicated that HCE is mostly localized and metabolized in the liver and kidney. Several corresponded metabolites have demonstrated liver and kidney toxicities similar to HCE. Neurological effects such as tremors and ataxia were observed in Beagle dogs, rats, and pregnant rats. Other effects via inhalation exposure included reduced body weight and increased relative liver weight in rats and guinea pigs. In another study, male rats also displayed increased relative spleen and testes weight. Based on California Proposition 65, HCE was proposed to be carcinogenic for humans, and it induces tumors at sites other than the site of entry. Noncancerous effects include kidney degeneration (tubular nephropathy, necrosis of renal tubular epithelium, hyaline droplet formation, tubular regeneration, and tubular casts) and hepatocellular necrosis. It results in hyaline droplet nephropathy and renal toxicity, and it induces chromosome malsegregation, lethality, and mitotic growth arrest (Crebelli et al., 1995, 1992, 1988).

Hexachloroethane is used as a solvent, infireworks and smoke devices; in explosives,in celluloid, as an insecticide, and as a rubbervulcanizing accelerator. Earlier it was used asan anthelmintic for livestock. Hexachloroethane is a highly efficient chlorinating agent in the preparation of chlorosilanes from hydrosilanes.

Safety

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H319-H351-H410
Precautionary statements  P202-P264-P273-P280-P305+P351+P338-P308+P313
Hazard Codes  Xn,N,T,F
Risk Statements  40-51/53-36/37/38-39/23/24/25-36/38-23/24/25-11-50/53-52/53
Safety Statements  36/37-61-45-36/37/39-26-24-16-7-37/39
RIDADR  UN 9037
OEB B
OEL TWA: 1 ppm (10 mg/m3) [skin] (Chloroethanes)
WGK Germany  3
RTECS  KI4025000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29031990
Hazardous Substances Data 67-72-1(Hazardous Substances Data)
Toxicity MLD i.v. in dogs: 325 mg/kg (Barsoum, Saad)
IDLA 300 ppm

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