(S)-3-Hydroxytetrahydrofuran , 98% , 86087-23-2

Synonym(s):
(S)-(+)-Tetrahydro-3-furanol

CAS NO.：86087-23-2

Empirical Formula: C4H8O2

Molecular Weight: 88.11

MDL number: MFCD00064327

EINECS: 1308068-626-2

PRODUCT Properties

• alpha: 18.5 º (c=2 MeOH)
• Boiling point: 80 °C/15 mmHg (lit.)
• Density: 1.103 g/mL at 25 °C (lit.)
• vapor pressure: 47Pa at 25℃
• refractive index: n20/D 1.45(lit.)
• Flash point: 175 °F
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Chloroform, Methanol (Slightly)
• pka: 14.49±0.20(Predicted)
• form: Liquid
• color: Clear colorless to pale yellow
• Specific Gravity: 1.11
• optical activity: [α]20/D +17.5°, c = 2.4 in methanol
• Water Solubility: soluble
• BRN: 4652609
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• InChIKey: XDPCNPCKDGQBAN-BYPYZUCNSA-N
• LogP: -0.784 at 22℃ and pH6.8
• Surface tension: 72mN/m at 1g/L and 25℃
• CAS DataBase Reference: 86087-23-2(CAS DataBase Reference)

Description and Uses

(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.

(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• HS Code: 29321900