Hesperitin , 97% , 520-33-2

Synonym(s):
3′,5,7-Trihydroxy-4′-methoxyflavanone;5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone

CAS NO.：520-33-2

Empirical Formula: C16H14O6

Molecular Weight: 302.28

MDL number: MFCD00075646

EINECS: 208-290-2

PRODUCT Properties

• Melting point: 230-232°C
• Boiling point: 363.32°C (rough estimate)
• Density: 1.2514 (rough estimate)
• refractive index: -4 ° (C=1.8, EtOH)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: 7.49±0.40(Predicted)
• form: Solid
• color: White to Pale Yellow
• Water Solubility: Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).
• Merck: 14,4670
• BRN: 309850
• InChIKey: AIONOLUJZLIMTK-AWEZNQCLSA-N
• LogP: 2.90

Description and Uses

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC₅₀ = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.

antiallergic

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37/39-27-37
• WGK Germany: 3
• HS Code: 29329990