Hesperitin , Analysis of standard products, ≥98% , 520-33-2
Synonym(s):
3′,5,7-Trihydroxy-4′-methoxyflavanone;5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone
CAS NO.：520-33-2
Empirical Formula: C16H14O6
Molecular Weight: 302.28
MDL number: MFCD00075646
EINECS: 208-290-2
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB142.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 230-232°C |
| Boiling point: | 363.32°C (rough estimate) |
| Density | 1.2514 (rough estimate) |
| refractive index | -4 ° (C=1.8, EtOH) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 7.49±0.40(Predicted) |
| form | Solid |
| color | White to Pale Yellow |
| Water Solubility | Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml). |
| Merck | 14,4670 |
| BRN | 309850 |
| InChIKey | AIONOLUJZLIMTK-AWEZNQCLSA-N |
| LogP | 2.90 |
| CAS DataBase Reference | 520-33-2(CAS DataBase Reference) |
Description and Uses
Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.
antiallergic
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-27-37 |
| WGK Germany | 3 |
| HS Code | 29329990 |
