Gimeracil , ≥98% , 103766-25-2

Synonym(s):
5-chloro-4-hydroxypyridin-2(1H)-one;5-Chloropyridine-2,4-diol;CDHP;Gimestat

CAS NO.：103766-25-2

Empirical Formula: C5H4ClNO2

Molecular Weight: 145.54

MDL number: MFCD08458352

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 274 °C
• Boiling point: 255.1±40.0 °C(Predicted)
• Density: 1.56±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 5 mg/ml).
• form: solid
• pka: 4.50±1.00(Predicted)
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N

Description and Uses

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Safety Statements: 24/25
• HS Code: 29337900