Glycopyrrolate , ≥98%(HPLC) , 596-51-0

Synonym(s):
Glycopyrrolate;glycopyrronium bromide;α-cyclopentylmandelic acid ester with 3-hydroxy-1,1-dimethylpyrrolidinium bromide;1-methyl-3-pyrrolidyl α-cyclopentylmandelate methobromide;1-methyl-3-pyrrolidyl α-phenyl-α-cyclopentylglycolate methobromide

CAS NO.：596-51-0

Empirical Formula: C19H28BrNO3-

Molecular Weight: 398.33

MDL number: MFCD00072137

EINECS: 209-887-0

PRODUCT Properties

• Melting point: 192-195°C
• Density: 1.3222 (rough estimate)
• refractive index: 1.6200 (estimate)
• storage temp.: 2-8°C
• solubility: H2O: ≥24mg/mL
• form: powder
• color: white to tan
• Merck: 14,4501
• Stability: Hygroscopic
• InChI: InChI=1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1
• InChIKey: VPNYRYCIDCJBOM-UHFFFAOYSA-M
• SMILES: C(O)(C(=O)OC1CC[N+](C)(C)C1)(C1=CC=CC=C1)C1CCCC1.[Br-]
• CAS DataBase Reference: 596-51-0(CAS DataBase Reference)

Description and Uses

Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs; K_is = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M₁-M₅ receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at concentrations of 0.01, 0.1, or 1 μM. Glycopyrrolate reduces post-prandial gastric antral motility in dogs when administered at a dose of 0.01 mg/kg. It inhibits salivation in a rat model of sialorrhea induced by pilocarpine with an ED₅₀ value of 0.74 μg/kg. Formulations containing glycopyrrolate have been used in the treatment of sialorrhea, peptic ulcers, and chronic obstructive pulmonary disease (COPD).

For use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubat

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: UY4337630
• HS Code: 29339900
• Toxicity: LD50 (72 hr.) in female mice, female rats (mg/kg): 107, 196 i.p.; in male rats (mg/kg): 1150 orally (Franko)