Ethyl 2-Hydroxyisobutyrate , >98.0%(GC) , 80-55-7
Synonym(s):
Ethyl 2-hydroxy-2-methylpropionate
CAS NO.：80-55-7
Empirical Formula: C6H12O3
Molecular Weight: 132.16
MDL number: MFCD00004458
EINECS: 201-290-3
PRODUCT Properties
| Melting point: | 78 °C |
| Boiling point: | 150 °C (lit.) |
| Density | 0.965 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 112 °F |
| storage temp. | Flammables area |
| pka | 13.28±0.29(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| BRN | 878308 |
| InChI | InChI=1S/C6H12O3/c1-4-9-5(7)6(2,3)8/h8H,4H2,1-3H3 |
| InChIKey | GFUIDHWFLMPAGY-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(O)(C)C |
| CAS DataBase Reference | 80-55-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2-hydroxy-2-methyl-, ethyl ester(80-55-7) |
| EPA Substance Registry System | Propanoic acid, 2-hydroxy-2-methyl-, ethyl ester (80-55-7) |
Description and Uses
Ethyl 2-hydroxyisobutyrate (E-2HIBA) has a wide range of applications in flavor and fragrance ingredients, green solvents, and pharmaceuticals. E-2HIBA has been synthesized by the batch transesterification of methyl 2-hydroxyisobutyrate with ethanol in the presence of titanium tetraethoxide (reaction conditions: 96 h, yield 97 %) and the esterification of 2-HIBA with an acid catalyst. The direct esterification of 2-HIBA with ethanol using an acid catalyst appears to be a commercially viable approach to produce E-2HIBA [1].
Solvent for nitrocellulose and cellulose acetate; solvent mixture for cellulose ethers, organic synthesis, pharmaceuticals.
Safety
| Symbol(GHS) |  GHS02 |
| Signal word | Warning |
| Hazard statements | H226 |
| Precautionary statements | P210-P370+P378 |
| Hazard Codes | Xi |
| Risk Statements | 10-36/37/38-36/38 |
| Safety Statements | 26-36-16 |
| RIDADR | UN 3272 3/PG 3 |
| WGK Germany | 3 |
| RTECS | OD5672000 |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29181980 |
