Guanosine-5'-triphosphate disodium salt , 90% , 56001-37-7

Synonym(s):
5′-GTP-Na₂;GTP;Guanosine 5′-triphosphate sodium salt hydrate

CAS NO.：56001-37-7

Empirical Formula: C10H14N5Na2O14P3

Molecular Weight: 567.14

MDL number: MFCD00083629

EINECS: 259-940-7

PRODUCT Properties

• Melting point: 180°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: PBS (pH 7.2): 10 mg/ml
• form: Powder
• color: White
• Water Solubility: Soluble in water.
• InChIKey: XIZYETZGWBYYEH-NGPBCCOENA-N
• SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,19,r|
• CAS DataBase Reference: 56001-37-7(CAS DataBase Reference)

Description and Uses

Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signalling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration.

Guanosine 5?-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exhange factors (GEF). Guanosine 5?-Triphosphate, Disodium Salt is a phosphoryl donor in protein synthesis and in signal transduction.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-27-36/37/39-36
• WGK Germany: 3
• F: 10-21
• HS Code: 29349990