Glucagon-Like Peptide 1 Fragment 7-37 human , ≥96%(HPLC) , 106612-94-6

Synonym(s):
GLP-1, 7-37;Preproglucagon 78-108

CAS NO.：106612-94-6

Empirical Formula: C151H228N40O47

Molecular Weight: 3355.67

MDL number: MFCD00167940

PRODUCT Properties

• Density: 1.48±0.1 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: Water:30.0(Max Conc. mg/mL);8.34(Max Conc. mM)
• form: Lyophilized powder
• color: White to off-white
• Water Solubility: Soluble in water at 2mg/ml
• Sequence: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH

Description and Uses

GLP-1 (7-37) is an endogenous truncated form of GLP-1 that arises from proglucagon processing in intestinal endocrine L cells, GLP-1 (7-37) acts as a GLP-1 receptor agonist and is an insulinotropic hormone that augments glucose induced insulin secretion. GLP-1 (7-37) and derivatives GLP-1 (9-37) and GLP-1 (28-37) can reduce plaque inflammation and increase phenotypic characteristics of plaque stability in a murine model of atherosclerosis.

Glucagon-Like Peptide 1 Fragment 7-37 human has been used:

• as a positive control for insulin secretion of pancreatic islets
• to test its effect on insulin response in horse islets
• in combination with mesenchymal stem cells (MSCs) test its protective effects in myocardial infarction

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3