D-Glucose 6-phosphate sodium salt , 97% , 54010-71-8

Synonym(s):
α-D-Glucose-6-phosphate, Monosodium Salt - CAS 54010-71-8 - Calbiochem;D(+)-Glucopyranose 6-phosphate sodium salt;G-6-P Na;Robison ester

CAS NO.：54010-71-8

Empirical Formula: C6H14NaO9P

Molecular Weight: 284.13

MDL number: MFCD00136039

EINECS: 258-921-0

PRODUCT Properties

• Melting point: 204 °C (dec.)(lit.)
• storage temp.: Sealed in dry,Room Temperature
• solubility: H₂O: 50 mg/mL, clear, colorless to very faintly yellow
• form: crystalline
• BRN: 5787568
• InChI: InChI=1/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;/t3-,4+,5+,6+;;/s3
• InChIKey: RUFPTDNHMAGVMV-IWNCBHIWNA-N
• SMILES: [C@@H](O)([C@H](O)COP(O)(O)=O)[C@H](O)[C@@H](O)C=O.[NaH] |&1:0,2,10,12,r|
• CAS DataBase Reference: 54010-71-8(CAS DataBase Reference)

Description and Uses

D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis. It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate activity leads to glycogen storage disease type I or von Gierke’s disease, a group of inherited metabolic diseases characterized by severe hypoglycemia, growth retardation, and hepatomegaly, due to accumulation of glycogen and fat in the liver. D-Glucose-6-phosphate is also the starting molecule of both glycolysis and the pentose phosphate pathways. Because cancer cells adopt glycolysis as a major source of metabolic energy production, and the pentose phosphate pathway plays a role in helping glycolytic cancer cells to meet their anabolic demands, this compound can be used to study the progression of this process.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P271-P280
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• F: 3-10
• HS Code: 29400000