6-Fluoroanthranilic Acid , >98.0% , 434-76-4

Synonym(s):
6-Fluoroanthranilic acid

CAS NO.：434-76-4

Empirical Formula: C7H6FNO2

Molecular Weight: 155.13

MDL number: MFCD00067781

EINECS: 627-707-2

PRODUCT Properties

• Melting point: 167-169 °C (lit.)
• Boiling point: 223.67°C (rough estimate)
• Density: 1.3021 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: soluble in Methanol
• pka: 4.01±0.10(Predicted)
• form: Crystalline Powder
• color: Yellow to brown
• BRN: 3540926
• InChIKey: RWSFZKWMVWPDGZ-UHFFFAOYSA-N
• CAS DataBase Reference: 434-76-4(CAS DataBase Reference)
• NIST Chemistry Reference: Anthralic acid, 6-fluoro-(434-76-4)

Description and Uses

Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29224999