2-Fluoroadenosine , ≥96.0% , 146-78-1

CAS NO.：146-78-1

Empirical Formula: C10H12FN5O4

Molecular Weight: 285.23

MDL number: MFCD00866394

EINECS: 633-923-8

PRODUCT Properties

• Melting point: 240 °C (D)(lit.)
• Boiling point: 747.3±70.0 °C(Predicted)
• Density: 2.17±0.1 g/cm3(Predicted)
• refractive index: -72 ° (C=0.1, EtOH)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
• form: Solid
• pka: 13.05±0.70(Predicted)
• color: Off-White
• InChI: InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
• InChIKey: HBUBKKRHXORPQB-UUOKFMHZSA-N
• SMILES: OC[C@H]1O[C@@H](N2C3C(=C(N=C(F)N=3)N)N=C2)[C@H](O)[C@@H]1O
• CAS DataBase Reference: 146-78-1(CAS DataBase Reference)

Description and Uses

2-Fluoroadenosine (F-Ado) was developed at Southern Research Institute in 1957 as a potential anticancer drug. 2-Fluoroadenosine is not deaminated by adenosine deaminase but metabolized to triphosphate as shown in vitro. The drug was also shown to be a potent inhibitor of lymphocyte-mediated cytolysis.

2-Fluoroadenosine is a fluorinated analog of Adenoside nucleotide. It is used as an intermediate for the drug fludarabine. Fludarabine is a purine analogue and antineoplastic agent. It is a chemotherapy medication used in the treatment of leukemia and lymphoma.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• RTECS: AU7386000
• HS Code: 29349990
• Toxicity: mouse,LD10,unreported,1000ug/kg (1mg/kg),Progress in Medical Chemistry. Vol. 7, Pg. 69, 1970.