Home Categories 3-(4-Fluorobenzoyl)propionic acid
A4377712

3-(4-Fluorobenzoyl)propionic acid , 97% , 366-77-8

Synonym(s):
Haloperidol metabolite III;R 11302

CAS NO.:366-77-8

Empirical Formula: C10H9FO3

Molecular Weight: 196.18

MDL number: MFCD00002793

EINECS: 206-679-1

Pack Size Price Stock Quantity
5G RMB71.20 In Stock
25G RMB177.60 In Stock
100G RMB647.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 100-102 °C (lit.)
Boiling point: 374.4±22.0 °C(Predicted)
Density  1.2441 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  powder to crystal
pka 4.50±0.17(Predicted)
color  White to Orange to Green
Water Solubility  Insoluble in water.
BRN  958145
CAS DataBase Reference 366-77-8(CAS DataBase Reference)

Description and Uses

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319-H302
Precautionary statements  P280g-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xn,C,Xi
Risk Statements  36/37/38-20/21/22-22
Safety Statements  36/37/39-26-22-24/25
WGK Germany  3
Hazard Note  Corrosive
HazardClass  IRRITANT
HS Code  29183000

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