3-(4-Fluorobenzoyl)propionic acid , 97% , 366-77-8
Synonym(s):
Haloperidol metabolite III;R 11302
CAS NO.：366-77-8
Empirical Formula: C10H9FO3
Molecular Weight: 196.18
MDL number: MFCD00002793
EINECS: 206-679-1
| Pack Size | Price | Stock | Quantity |
| 5G | RMB71.20 | In Stock |
|
| 25G | RMB177.60 | In Stock |
|
| 100G | RMB647.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 100-102 °C (lit.) |
| Boiling point: | 374.4±22.0 °C(Predicted) |
| Density | 1.2441 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | powder to crystal |
| pka | 4.50±0.17(Predicted) |
| color | White to Orange to Green |
| Water Solubility | Insoluble in water. |
| BRN | 958145 |
Description and Uses
7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H335-H315-H319-H302 |
| Precautionary statements | P280g-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| Hazard Codes | Xn,C,Xi |
| Risk Statements | 36/37/38-20/21/22-22 |
| Safety Statements | 36/37/39-26-22-24/25 |
| WGK Germany | 3 |
| Hazard Note | Corrosive |
| HazardClass | IRRITANT |
| HS Code | 29183000 |
