A4365212
Fosaprepitant dimeglumine salt , ≥99% , 265121-04-8
CAS NO.：265121-04-8
Empirical Formula: C60H78F14N10O20P2
Molecular Weight: 1587.24
MDL number: MFCD23102059
EINECS: 682-419-4
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB409.60 | In Stock |
|
| 10MG | RMB558.40 | In Stock |
|
| 50MG | RMB2008.80 | In Stock |
|
| 100mg | RMB4879.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | ≥50.24 mg/mL in DMSO; insoluble in EtOH; ≥13.16 mg/mL in H2O with ultrasonic |
| form | Powder |
| pka | Fosaprepitant dimeglumine has four functional groups which have pKa values of 3.05 ± 0.03, 4.92 ± 0.02, 9.67 ± 0.01 and 10.59 ± 0.03. The pka value of 3.05 corresponds to the morpholinium group, the pka of 4.92 corresponds to the monophosphonate group, the pka of 9.67 corresponds to the meglumine counter ion, and the pka of 10.59 corresponds to the triazolinone NH group. |
| color | White to off-white |
Description and Uses
Fosaprepitant dimeglumine belongs to the group of antiemetics. The active substance inhibits part of the vomiting centre. It is used for the treatment of postoperative or chemotherapyinduced nausea and vomiting.
Fosaprepitant is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
