Home Categories API Aprepitant
A0770312

Aprepitant , ≥98% , 170729-80-3

Synonym(s):
Aprepitant;Emend;3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one;3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

CAS NO.:170729-80-3

Empirical Formula: C23H21F7N4O3

Molecular Weight: 534.43

MDL number: MFCD08277635

EINECS: 677-636-6

Pack Size Price Stock Quantity
5MG RMB23.20 In Stock
25MG RMB31.20 In Stock
100MG RMB39.20 In Stock
250mg RMB51.20 In Stock
500mg RMB87.20 In Stock
1g RMB159.20 In Stock
5g RMB595.20 In Stock
25g RMB1787.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 244-246°C
alpha  D25 +69° (c = 1.00 in methanol)
Density  1.51±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  Soluble in DMSO (>25 mg/ml)
pka 8.06±0.20(Predicted)
form  powder
color  white to beige
optical activity [α]/D +61 to +71°, c = 1.0 in methanol
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey ATALOFNDEOCMKK-OITMNORJSA-N
SMILES N1C(CN2CCO[C@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)[C@@H]2C2=CC=C(F)C=C2)=NC(=O)N1
CAS DataBase Reference 170729-80-3(CAS DataBase Reference)

Description and Uses

Aprepitant is an antiemetic chemical compound that belongs to “substance P” antagonists (SPA) with its effect being blocking the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayedchemotherapy-induced nausea and vomiting(CINV) and for prevention ofpostoperative nausea and vomiting. It can also be used for the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting occurring during cancer treatment. Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is a G-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex.

anticholinergic

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H319-H351
Precautionary statements  P501-P202-P201-P264-P280-P308+P313-P337+P313-P305+P351+P338-P405
HS Code  2934990002

RELATED PRODUCTS