A4314612
Fmoc-Ser(tBu)-OH , 98% , 71989-33-8
Synonym(s):
Fmoc-O-tert-butyl-L -serine;Fmoc-Ser(tBu)-OH;N-α-Fmoc-O-t.-butyl-L-serine
CAS NO.：71989-33-8
Empirical Formula: C22H25NO5
Molecular Weight: 383.44
MDL number: MFCD00037127
EINECS: 276-260-6
| Pack Size | Price | Stock | Quantity |
| 5G | RMB24.00 | In Stock |
|
| 25G | RMB111.20 | In Stock |
|
| 100G | RMB415.20 | In Stock |
|
| 500g | RMB2031.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 130.5-135.5 °C(lit.) |
| alpha | 25 º (c=1,EtOAc 24 ºC) |
| Boiling point: | 510.36°C (rough estimate) |
| Density | 1.2369 (rough estimate) |
| refractive index | 24 ° (C=1, AcOEt) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder to crystal |
| pka | 3.44±0.10(Predicted) |
| color | White to Almost white |
| optical activity | [α]20/D +25.5±1°, c = 1% in ethyl acetate |
| BRN | 3632013 |
| InChI | InChI=1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1 |
| InChIKey | REITVGIIZHFVGU-IBGZPJMESA-N |
| SMILES | C(O)(=O)[C@H](COC(C)(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
Description and Uses
Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:
- Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.
- Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.
- Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36/37/39-27-26 |
| WGK Germany | 3 |
| HS Code | 29242990 |
