Fmoc-Ser(tBu)-OH , 98% , 71989-33-8

Synonym(s):
Fmoc-O-tert-butyl-L-serine;Fmoc-Ser(tBu)-OH;N-α-Fmoc-O-t.-butyl-L-serine

CAS NO.：71989-33-8

Empirical Formula: C22H25NO5

Molecular Weight: 383.44

MDL number: MFCD00037127

EINECS: 276-260-6

PRODUCT Properties

• Melting point: 130.5-135.5 °C(lit.)
• alpha: 25 º (c=1,EtOAc 24 ºC)
• Boiling point: 510.36°C (rough estimate)
• Density: 1.2369 (rough estimate)
• refractive index: 24 ° (C=1, AcOEt)
• storage temp.: 2-8°C
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• form: powder to crystal
• pka: 3.44±0.10(Predicted)
• color: White to Almost white
• optical activity: [α]20/D +25.5±1°, c = 1% in ethyl acetate
• BRN: 3632013
• InChI: InChI=1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
• InChIKey: REITVGIIZHFVGU-IBGZPJMESA-N
• SMILES: C(O)(=O)[C@H](COC(C)(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
• CAS DataBase Reference: 71989-33-8(CAS DataBase Reference)

Description and Uses

Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:

• Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.
• Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.
• Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 24/25-36/37/39-27-26
• WGK Germany: 3
• HS Code: 29242990