Florfenicol , Analysis standard , 73231-34-2

Synonym(s):
[R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide;Aquafen;Nuflor;SCH-25298

CAS NO.：73231-34-2

Empirical Formula: C12H14Cl2FNO4S

Molecular Weight: 358.21

MDL number: MFCD00864834

EINECS: 642-986-0

PRODUCT Properties

• Melting point: 153 °C
• Boiling point: 618℃
• alpha: 26 +17.9° (DMF)
• Density: 1.451±0.06 g/cm3(Predicted)
• RTECS: DB6034000
• Flash point: >110°(230°F)
• storage temp.: Inert atmosphere,2-8°C
• solubility: Soluble in ethanol to 25mM and in DMSO to 100mM
• pka: 10.73±0.46(Predicted)
• form: solid
• color: White to Off-White
• Merck: 14,4109
• InChI: InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
• InChIKey: AYIRNRDRBQJXIF-NXEZZACHSA-N
• SMILES: C(N[C@H](CF)[C@H](O)C1=CC=C(S(C)(=O)=O)C=C1)(=O)C(Cl)Cl

Description and Uses

Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol . It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC₅₀s = 6.3-12.5 μg/ml). Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC₅₀s = 0.25-4 μg/ml). It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM. Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.

Florfenicol is a fluorinated derivative of thiamphenicol. It is a protein synthesis inhibitor that inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H410-H400-H361-H372
• Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P273-P391-P501-P273-P391-P501-P260-P264-P270-P314-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HS Code: 29419090