Home Categories Biochemical Engineering Fmoc-Asn(Trt)-OH
A4300112

Fmoc-Asn(Trt)-OH , 97% , 132388-59-1

Synonym(s):
Nα-(9-Fluorenylmethoxycarbonyl)-Nγ-trityl-L-asparagine;Nα-Fmoc-Nγ-trityl-L-asparagine;FMOC-Asn(Trt)-OH;N-α-Fmoc-N-β-trityl-L-asparagine

CAS NO.:132388-59-1

Empirical Formula: C38H32N2O5

Molecular Weight: 596.67

MDL number: MFCD00077049

Pack Size Price Stock Quantity
1g RMB35.20 In Stock
5G RMB36.80 In Stock
25G RMB128.00 In Stock
100G RMB454.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 201-204 °C(lit.)
alpha  -16 º (c=1, MeOH)
Boiling point: 858.1±65.0 °C(Predicted)
Density  1.271±0.06 g/cm3(Predicted)
refractive index  -19 ° (C=1, DMF)
storage temp.  2-8°C
solubility  <0.00005g/l
pka 3.79±0.10(Predicted)
form  powder to crystal
color  White to Almost white
optical activity [α]20/D 15.0±1°, c = 1% in methanol
BRN  4343823
InChIKey KJYAFJQCGPUXJY-UUWRZZSWSA-N
SMILES C(O)(=O)[C@H](CC(N)=O)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference 132388-59-1(CAS DataBase Reference)

Description and Uses

Fmoc-Asn(Trt)-OH prevents the possibility of the amide side chain from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Asn(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Asn-OH is only somewhat soluble in NMP or DMF. The trityl group is removed with TFA. This reaction is usually complete within 1 hour at room temperature, but is slower when the Asn(Trt) residue in at the N-terminal of the peptide. In these cases, the deprotection reaction should be extended to 2 hours.

Fmoc-Asn(Trt)-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.

Safety

Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H411
Precautionary statements  P273-P391-P501
Risk Statements  53
Safety Statements  24/25-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  2
3-10
HS Code  2924 29 70
HazardClass  IRRITANT
Toxicity LD50 orally in Rabbit: > 2000 mg/kg

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