Home Categories Biochemical Engineering 6-Hydroxydopamine hydrobromide
A4289520

6-Hydroxydopamine hydrobromide , 95% , 636-00-0

Synonym(s):
2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide;2,4,5-Trihydroxyphenethylamine hydrobromide;2,5-Dihydroxytyramine hydrobromide;6-OHDA

CAS NO.:636-00-0

Empirical Formula: C8H12BrNO3

Molecular Weight: 250.09

MDL number: MFCD00012894

EINECS: 211-247-0

Pack Size Price Stock Quantity
10MG RMB71.20 In Stock
50mg RMB239.20 In Stock
250mg RMB479.20 In Stock
1g RMB1583.20 In Stock
5g RMB6399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 216-220 °C(lit.)
storage temp.  -20°C
solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  solid
color  tan to brown
BRN  3713280
Stability: Hygroscopic, Light Sensitive
InChIKey MLACDGUOKDOLGC-UHFFFAOYSA-N
CAS DataBase Reference 636-00-0(CAS DataBase Reference)

Description and Uses

6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.

6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DC4600000
3-10

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