Fmoc-Leu-OH , 98% , 35661-60-0

Synonym(s):
N-(9-Fluorenylmethoxycarbonyl)-L-leucine;Fmoc-L-leucine;Fmoc-Leu-OH;N-α-Fmoc-L-leucine

CAS NO.：35661-60-0

Empirical Formula: C21H23NO4

Molecular Weight: 353.41

MDL number: MFCD00037133

EINECS: 252-662-7

PRODUCT Properties

• Melting point: 152-156 °C(lit.)
• alpha: -26 º (c=1,DMF 24 ºC)
• Boiling point: 486.83°C (rough estimate)
• Density: 1.2107 (rough estimate)
• refractive index: -25 ° (C=1, DMF)
• storage temp.: Store below +30°C.
• solubility: DMF (Slightly), DMSO (Slightly)
• pka: 3.91±0.21(Predicted)
• form: Solid
• color: White to Off-White
• optical activity: [α]20/D 25±2°, c = 1% in DMF
• BRN: 2178254
• Stability: Hygroscopic
• InChIKey: CBPJQFCAFFNICX-IBGZPJMESA-N

Description and Uses

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36/37/39-27-26
• WGK Germany: 3
• HS Code: 2924 29 70