Ramipril , ≥98%(HPLC) , 87333-19-5

Synonym(s):
[2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid;Tritace

CAS NO.：87333-19-5

Empirical Formula: C23H32N2O5

Molecular Weight: 416.51

MDL number: MFCD00865775

EINECS: 642-904-3

PRODUCT Properties

• Melting point: 106-108°C
• alpha: D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
• Boiling point: 616.2±55.0 °C(Predicted)
• Density: 1.200±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ~18mg/mL
• pka: pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
• form: powder
• color: white
• BCS Class: 1

Description and Uses

Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.

An inhibitor of the angiotensin- coverting enzyme (ACE)

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360FD
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi
• Risk Statements: 36/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: GY5879600
• HS Code: 2933995300
• Toxicity: LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)