A4224414
Ramipril , ≥98%(HPLC) , 87333-19-5
Synonym(s):
[2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid;Tritace
CAS NO.:87333-19-5
Empirical Formula: C23H32N2O5
Molecular Weight: 416.51
MDL number: MFCD00865775
EINECS: 642-904-3
Pack Size | Price | Stock | Quantity |
100mg | RMB23.20 | In Stock |
|
1g | RMB46.40 | In Stock |
|
500mg | RMB47.20 | In Stock |
|
5g | RMB148.80 | In Stock |
|
25g | RMB565.60 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 106-108°C |
Boiling point: | 616.2±55.0 °C(Predicted) |
alpha | D24 +33.2° (c = 1 in 0.1N ethanolic HCl) |
Density | 1.200±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ~18mg/mL |
pka | pKa 3.30±0.01(H2O
t = 25.0
I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O
t = 25.0
I = 0.15 (KCl)) (Uncertain) |
form | powder |
color | white |
BCS Class | 1 |
CAS DataBase Reference | 87333-19-5(CAS DataBase Reference) |
Description and Uses
Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.
An inhibitor of the angiotensin- coverting enzyme (ACE)
Safety
Symbol(GHS) | GHS08 |
Signal word | Danger |
Hazard statements | H360FD |
Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
Hazard Codes | Xi |
Risk Statements | 36/38 |
Safety Statements | 26-37/39 |
WGK Germany | 2 |
RTECS | GY5879600 |
HS Code | 2933995300 |
Hazardous Substances Data | 87333-19-5(Hazardous Substances Data) |
Toxicity | LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer) |