Eprinomectin , ≥91% , 123997-26-2

Synonym(s):
(4′’R)-4″-(Acetylamino)-4″-deoxy-avermectin B₁ solution;(4′’R)-4″-(Acetylamino)-4″-deoxy-avermectin B₁;Eprinomectin;Mixture of component B1a and component B1b

CAS NO.：123997-26-2

Empirical Formula: C50H75NO14

Molecular Weight: 914.129

MDL number: MFCD07370747

EINECS: 602-966-4

PRODUCT Properties

• Melting point: 163-166°C
• Density: 1.23
• Flash point: 2 °C
• storage temp.: 2-8°C
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
• form: Solid
• color: White to off-white
• Stability: Hygroscopic

Description and Uses

Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%).Eprinomectin was developed as a topical endectocide for all categories of cattle including lactating dairy cattle, and the process by which eprinomectin was selected for further development has been described (90). Briefly, several hundred avermectin/ milbemycin analogues were screened in a sheep model for efficacy against a range of endoparasites and in lactating dairy cows for a low milk:plasma partitioning ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin, by comparison, partitions equally between milk and plasma.

Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect.

Safety

• Symbol(GHS): GHS06,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H301-H361-H410
• Precautionary statements: P201-P273-P301+P310+P330
• Hazard Codes: F,Xn,N,T
• Risk Statements: 11-20/21/22-36-62-50/53-25-63
• Safety Statements: 26-36/37-16-61-60-45
• RIDADR: UN 2811
• WGK Germany: 3
• HS Code: 2941906000
• Toxicity: LD50 orally in mice: 24 mg/kg (Jones)